2025 Impact Report: A Year of Momentum, Milestones, and Measurable Progress

This year, the HHT community proved—again—that determination moves mountains.

Our 2025 Impact Report highlights a year defined by scientific breakthroughs, expanded clinical access, and the relentless drive of patients, families, clinicians, and supporters who believe in a world where HHT is found early, treated effectively, and ultimately cured.

From pushing new research forward to strengthening our global network of HHT Centers of Excellence, the milestones showcased in this year’s report reflect one truth: progress doesn’t happen by accident. It happens because people refuse to settle for the status quo.

Inside the report, you’ll find:

• Major advancements in the research pipeline, including new therapeutic targets and more treatments under investigation than ever before

• Growing access to expert HHT care, with more patients receiving timely diagnosis and evidence-based management

• Education and awareness initiatives reaching broader audiences, empowering families to advocate for themselves

• Community stories that capture resilience, hope, and the urgency of our mission

These wins are powerful—but they are also a starting point.

You Can Help Build What Comes Next

As we close out the year, our Blueprint to a Cure campaign is underway, fueling the next phase of research and care. Thanks to several generous donors, we have a year-end matching opportunity designed to inspire giving and accelerate impact.

Every contribution made now helps unlock these matching funds—doubling the momentum for families who need answers, treatments, and hope.

If the progress in this year’s Impact Report resonates with you, we invite you to be part of what’s coming next.

Read the full 2025 Impact Report: 2025 Impact Report

Make your year-end gift to Blueprint to a Cure: curehht.org/donate

Together, we’re building the pathway to a future where HHT no longer shortens or limits lives. And we’re not letting up now.