AVM Progression and Regression – Findings from a Notch-Mediated Mouse Model of Brain AVM (recorded)

Dr. Rong Wang, Professor and Mildred V. Strouss Endowed Chair in Vascular Surgery in the Department of Surgery at the University of California, San Francisco, discusses her recent discoveries presented at the 2015 International HHT Scientific Conference. These findings provide unprecedented insight uncovered from studying Brain AVM formation, and regression, in real time with high resolution microscopy in live animals with HHT. Dr. Wang’s studies advance our understanding of how HHT disease is initiated and inspire new strategies in the development of treatment options. Webinar highlights include: an explanation of notch signaling and its relevance to HHT, the cause for increase in notch signaling human brain AVMs, and the remarkable similarities between notch and HHT2 (Alk1 or ACVRL1). The presentation is followed by a Q&A discussion with webinar attendees.